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What is ketamine-assisted psychotherapy (KAP)?

An approach in psychiatric care that pairs ketamine, which can temporarily alter consciousness, with psychological support from trained clinicians. It is not medication alone: preparation, the session, and integration form one continuous process.

This treatment is not a substitute for standard care. In Japan it is an off-label use, offered as private care not covered by insurance. We explain the risks at the first visit.

For first-time patients →

When nothing seems to help.

You change medications. You give it time. Still, no clear way out. That does not mean you have not tried hard enough.

Ketamine-assisted psychotherapy (KAP) is one further option for people who have not found sufficient relief so far. We can begin by carefully asking whether it may be a fit for you.

Free consultation & eligibility check →

Prepare. Experience. Integrate.

KAP is more than the medication itself. From psychiatric assessment through preparation, the session, integration, and follow-up, physicians and mental health professionals work together throughout. During sessions we monitor continuously, keeping safety first.

Dr. Norihide Ensako, Director of HIKARI CLINIC

Meet the doctor

Norihide Ensako

HIKARI CLINIC Director / Psychiatrist

Another option for people who have not found enough relief so far. We stay beside you through the whole arc of prepare, experience, and integrate into daily life.

View doctor profile →

Start by finding out if it fits.

Treatment process

Ketamine-assisted psychotherapy proceeds in five steps, with physicians and mental health professionals working together.

  1. 01

    Initial consultation & assessment

    About 60 minutes

    A psychiatrist reviews history, current symptoms, and co-occurring conditions to judge whether KAP is appropriate.

  2. 02

    Preparation session

    1–2 hoursSame day

    In a session with a mental health professional, you build readiness and share the aims of psychologically supported care before the dosing day.

  3. 03

    Ketamine session

    About 2.5–3 hours in clinicSame day

    Under continuous clinical monitoring and careful physician-led dosing, the session takes place.

  4. 04

    Integration session

    1 hourSame day

    Always held after the ketamine session. You reflect with a mental health professional and begin weaving the experience into daily life.

  5. 05

    Two-week follow-up integration

    Online available

    About two weeks later, we review changes in symptoms and daily life and consider ongoing plans.

See the full treatment process →

Who may be suitable

  • Treatment-resistant depression
  • Depression with strong suicidal ideation
  • Depressive episodes in bipolar disorder
  • PTSD (post-traumatic stress disorder)
  • Obsessive-compulsive disorder
  • End-of-life care

Clinical studies have reported antidepressant effects, but how change appears varies from person to person, and not everyone experiences the same outcome. This treatment is not a substitute for standard care. Suitability is decided individually at the first-visit assessment.

We may not be able to offer treatment for safety reasons, for example a history of schizophrenia, uncontrolled hypertension or heart disease, or pregnancy / breastfeeding.

See who this treatment is for →

Fees

Initial consultation & assessment

16,500 YENPrivate care (not covered by insurance)

Plan A

Single session

148,500 YEN

Private care (not covered by insurance)

  • 1 ketamine session
  • 1 preparation session
  • 1 integration session
  • 1 follow-up integration ~2 weeks later

Plan B

3-session course

297,000 YEN

Private care (not covered by insurance)

  • 3 ketamine sessions

Plan C

Standard program

6-session course

528,000 YEN

Private care (not covered by insurance)

  • 6 ketamine sessions

Fees & settlement details →

FAQ

What effects can ketamine-assisted psychotherapy have?
Clinical research overseas has reported antidepressant effects for treatment-resistant depression. Improvement has been described within hours to about 24 hours after dosing. At the first visit we explain the research overview and its limits. For details, see the Who it's for page.
I am worried about dissociation. Is that okay?
Dissociative experiences (shifts in the sense of reality) can occur during a ketamine session. This can be part of the drug’s expected effects, and clinicians monitor you throughout. In the preparation session we explain the nature of the experience and how to meet it.
What should I know on the day of the session?
Please refrain from food and drink that day (small amounts of water are fine). For 24 hours after the session, do not drive a car or motorcycle, or do hazardous work. Details are covered at the first visit and in preparation.
Can I keep taking my current medications?
Depending on what you take, adjustments before or after a session may be needed. Please share all medications at the first visit. A physician will review safety and give individual guidance. Do not change medications on your own.

See all questions →

Important note on off-label use

The ketamine-assisted psychotherapy we provide is an off-label use not approved for this indication in Japan. Before treatment begins, we ask you to understand the risks, side effects, and that this is private care, then sign a consent form.

Read the important notice →

Begin with a conversation.

If something is on your mind, start gently. Free online consultations are available.